Improving the understanding and modelling of drug transporters to better predict drug-drug interactions and enhance interaction study efficiency

Pharma IQ are pleased to announce the dates for the Clinically Relevant Drug Transporters conference taking place on the 30th June – 1st July 2010. The emerging field of drug transporters is constantly evolving, particularly with the new ITC guidelines.

Since the publication of the much-anticipated International Transporter Consortium paper was announced, there has been much industry and academic debate as to its content and impact on the field of transporters. The Clinically Relevant Drug Transporters conference offers you the first chance in Europe to meet with senior figures and peers working with transporters to discuss the ITC paper, as well as to gain an increased understanding and hear what your peers have been doing in the field.

Join us in London to discuss the key clinically relevant drug transporters, predicting drug-drug interactions, specific transporter-related substrates and inhibitors, the FDA stance on clinical interaction studies and labelling, the newest and most effective modelling and IVIVE techniques and much more!

Key topics to be discussed:

• Evaluating the impact of the new ITC paper, including FDA guidelines and decision trees
• Methods for studying drug-transporter interactions
• New techniques to study ABC (efflux) and SLC (uptake) drug transporters
• The most effective methods for in silico modelling and in vitro-in vivo extrapolation (IVIVE)
• Increasing efficacy and reducing toxicity through improved prediction of transporter-mediated drug-drug interactions (DDIs)
• The regulatory attitude towards data submission and NME labelling

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